Home > Press > Gold Nanorods Detect Ovarian Cancer, Improve Surgical Removal in Mice
Abstract:
Using gold nanorods that are visible using two different types of imaging techniques, researchers at the Stanford University Center for Cancer Nanotechnology Excellence and Translation (Stanford CCNE-T) have developed a promising new method that may be able to detect early stage ovarian cancer and help surgeons completely remove the detected tumor. The researchers have successfully tested this imaging agent in an animal model of human ovarian cancer and are already working on an improved agent that may be able to discriminate between malignant and benign ovarian masses. The Stanford CCNE-T team, led by Sanjiv Sam Gambhir, reported its findings in the journal ACS Nano.
Ovarian cancer is the fifth most common cancer among women, and it causes more deaths than any other type of female reproductive cancer, largely because ovarian cancer symptoms are vague and it most often goes undiagnosed until it has spread to other parts of the body. However, when detected early, the five-year survival rate is as high as 95 percent, so the development of non-invasive and inexpensive technology to detect early stage ovarian cancer could have a profound impact on patient survival.
To create their new imaging agent, Dr. Gambhir's team took advantage of the unique properties of gold nanorods, which interact strongly with light in a variety of useful ways. For example, gold nanorods will absorb near-infrared light and produce heat that creates a pressure wave that can be detected with standard ultrasound devices that are already used widely in doctor's offices. This technique is known as photoacoustic spectroscopy. Gold nanorods will also generate a well-defined optical emission that can be detected using surface-enhanced Raman spectroscopy (SERS), another well-established measurement technology.
Another useful property of nanorods in general is that their shape somehow enables them to accumulate more effectively than spherical particles around tumors. Researchers assume that the long, thin shape enables the rods to more easily penetrate and escape the leaky blood vessels that surround tumors.
To assess the imaging capabilities of gold nanorods, the investigators created three different batches that varied in the ratio of their length to width, also known as the aspect ratio. Based on the intensity of the photoacoustic signal and the Raman signal, the researchers settled on a gold nanorod with an aspect ratio of 3.5 (756 nm absorbance) for further testing. When injected intravenously into mice bearing human ovarian tumors, these gold nanorods were readily detected through the skin in and around tumors in live animals. The researchers noted that the photoacoustic signal from the injected nanorods remained stable for three days, while signal from nanorods circulating in blood returned to baseline levels within 24 hours, a desirable trait for a clinically useful imaging agent.
Next, Dr. Gambhir and his colleagues used the SERS signal to guide surgical removal of the tumors. Presurgical images clearly showed the location and edges, or margins, of even small tumors, and post-surgical imaging confirmed that all traces of tumor were removed.
Though the photoacoustic signal from the gold nanorods can be detected through as much as 4 centimeters (just over 1.5 inches) of tissue, Dr. Gambhir and his colleagues are developing photoacoustic catheters that will further increase the number of accessible sites. They are also developing nanorods targeted specifically to malignant ovarian tumors that would not only accumulate better in tumors, but may also be able to distinguish malignant from benign ovarian masses.
####
About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.
Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today?s explosion in knowledge.
For more information, please click here
Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
Copyright ? The National Cancer Institute (NCI)
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
View abstract - This work, which is detailed in a paper titled, ?Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice,? was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's website:
News and information
Measuring flow using a tiny wobbling tube December 18th, 2012
Analytical Community Rewards Postnova System with 2012 Innovations Award December 18th, 2012
New technology may enable earlier cancer diagnosis Nanoparticles amplify tumor signals, making them much easier to detect in the urine. December 17th, 2012
Nanoifibers clean sulfur from fuel December 17th, 2012
New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream December 17th, 2012
Imaging
Nanoparticles Glow through Thick Layer of Tissue December 17th, 2012
Govt.-Legislation/Regulation/Funding/Policy
Nano-Enabled Paper Detects Kidney Cancer Markers December 17th, 2012
Nanoparticles Glow through Thick Layer of Tissue December 17th, 2012
New technology may enable earlier cancer diagnosis Nanoparticles amplify tumor signals, making them much easier to detect in the urine. December 17th, 2012
Nanoifibers clean sulfur from fuel December 17th, 2012
Nanomedicine
Measuring flow using a tiny wobbling tube December 18th, 2012
Nano-Enabled Paper Detects Kidney Cancer Markers December 17th, 2012
Nanoparticles Glow through Thick Layer of Tissue December 17th, 2012
New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream December 17th, 2012
Discoveries
Nanoparticles Glow through Thick Layer of Tissue December 17th, 2012
Tissue engineering: Growing new organs, and more: Research could lead to better ways to heal injuries and develop new drugs December 17th, 2012
New technology may enable earlier cancer diagnosis Nanoparticles amplify tumor signals, making them much easier to detect in the urine. December 17th, 2012
Nanoifibers clean sulfur from fuel December 17th, 2012
Announcements
Measuring flow using a tiny wobbling tube December 18th, 2012
Analytical Community Rewards Postnova System with 2012 Innovations Award December 18th, 2012
New technology may enable earlier cancer diagnosis Nanoparticles amplify tumor signals, making them much easier to detect in the urine. December 17th, 2012
Nanoifibers clean sulfur from fuel December 17th, 2012
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals
Nano-Enabled Paper Detects Kidney Cancer Markers December 17th, 2012
Ceramics in Paper Manufacturing including Advanced and Nano Materials December 17th, 2012
Research and Markets: The Global Nanotechnology and Nanomaterials Industry 2013 Report: Stage of Development, Global Activity and Market Opportunities December 16th, 2012
mPhase Technologies Profile Distributed by European Publication December 14th, 2012
Tools
Measuring flow using a tiny wobbling tube December 18th, 2012
Analytical Community Rewards Postnova System with 2012 Innovations Award December 18th, 2012
Oxford Instruments plc Acquires Asylum Research Corp. December 17th, 2012
New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream December 17th, 2012
Source: http://www.nanotech-now.com/news.cgi?story_id=46611
Jenni Rivera Alive Facebook Down bo jackson bo jackson hanukkah ufc justin tv
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.